Expression of interleukin-13 receptor and its relationship to proliferation activity of human gliomas
- VernacularTitle:人脑胶质瘤白介素13受体基因表达与肿瘤增殖活性的关系研究
- Author:
Zhi-Bai XIA
;
Xin-Jian WU
;
Tie-Wei QI
;
Hai-Jun WANG
;
Zheng-Song HUANG
;
- Publication Type:Journal Article
- Keywords:
Glioma;
Interleukin-13 receptor;
Gene expression
- From:
Chinese Journal of Microsurgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the gene expression of interleukin-13 receptor (IL-13R)?2 and its relationship to proliferation activity of human gliomas.Methods The gene expression of IL-13R?in 50 hu- man gliomas,2 malignant human glioma cell lines and 6 normal brain tissues were studied by RT-PCR.Ki-67 labeling index (Ki267 LI) of all sample were detecteded by immunohistochemical staining.Results Only one normal brain tissues expressed very low IL-13R?2 mRNA,whereas 35 (70%) of 50 human brain tumors expressed 1L-13R?2 mRNA.The positive rate and expression level of IL-13R?2 mRNA were increased with the ascending of WHO tumor grade.(former:rs=0.87;letter:rs=0.69,P＜0.01).The difference of posi- tive rate and expression level of IL-13R 2?mRNA between the low grade and high grade tumors was statistical- ly significant,the proliferation activity of gliomas evaluated by Ki-67LI (Ki-67 Labeling Index,Ki-67LI) was positively correlated with IL-13R?2 gene expression and the tumor grade.Conclusion In human cerebral gliomas,IL-13R?2 genes may play an role in the malignant progression.The expression level of malignancy in molecular level and selecting the target of gene therapy.
