Serum levels of HMGB-1 and organ dysfunction and death in patients with multiple trauma
- VernacularTitle:血清高迁移率蛋白-1水平变化与多发伤患者脏器功能不全及死亡率的关系
- Author:
Jun FEI
;
Hong-Jun YU
;
Hua-Ping LIANG
;
Xian-Kai HUANG
;
Yao-Guang JIANG
;
- Publication Type:Journal Article
- Keywords:
Multiple trauma;
High mobility group proteins;
Organ dysfunction;
Mortality
- From:
Chinese Journal of Trauma
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of serum level of high mobility group box-1(HMGB- 1)in patients with multiple trauma in order to forecast organ dysfunction(OD)and deaths.Methods The optical densities of HMGB-1 in serum of 35 patients with multiple trauma were determined on 1st,3rd, and 7th days after trauma,and the incidence of organ dysfunction and deaths were evaluated,then analyzed statistically to learn the relation between the serum levels of HMGB-1 and deaths with an attempt of predic- ting the incident of organ dysfunction and deaths.Results (1)As OD was concerned,there was a statis- tically significant difference in optical density of HMGB-1 on 1st and 3rd days between the two groups of multiple injury patients(t=4.411,P
