Study of correlation between expression of matrix matalloproteinase-9 and cerebral edema after diffuse brain injury in rats
- VernacularTitle:基质金属蛋白酶-9在大鼠弥漫性脑损伤中表达及与脑水肿相关性研究
- Author:
Chong WANG
;
Xian-Li ZHU
;
Hong-Yang ZHAO
;
Yu LI
;
Jin-Xing LI
;
Jia-Shan ZHAO
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Gelatinases;
Blood brain barrier;
Brain edema
- From:
Chinese Journal of Trauma
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of matrix metalloproteinase-9 mRNA and the change of cerebral edema after diffuse brain injury in rats and discuss their correlation.Methods Marmaruu's diffuse brain injury model of rat was made.Real-time quantitative RT-PCR,dry-wet meth- od,histological techniques and electron microscope were used to determine the expressions of MMP-9 containing water in brain tissue and inflammatory reaction and uhrastructural changes of blood capillary at different time phases after truama.Results The expressions of MMP-9 mRNA started to increase at 1 hour,peaked at 12 hours(P
