Protective effects of mixed crystamn on injured retinal ganglion cells after optic nerve injury in Long-Evans rats
- VernacularTitle:混合晶状体蛋白对大鼠视神经损伤后视网膜神经节细胞的保护作用
- Author:
Zhi-Min LIU
;
Lei REN
;
Yi WANG
;
Hong WANG
;
Yu-Xiao ZENG
;
- Publication Type:Journal Article
- Keywords:
Crystallins;
Retinal ganglion cells;
Optic nerve;
Transection
- From:
Chinese Journal of Trauma
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intraocular injection of mixed crystalline in vivo on survival of retinal ganglion cells(RGCs)after optic nerve cut.Methods Twenty Long-Evens rats were divided into normal control,and 7 day,14 day,and 21 day groups after optic nerve was cut off.There were 5 eyes in each group.Mixed crystallin(1x10~(-4)g/L)and isotonic saline solution were injected into the vitreous of fight eye and left eye respectively.The number of RGCs was counted 7,14 and 21 days after optic nerve cut.Results The density of RGCs declined clearly 7 days after optic nerve cut.In the group with crystallin injection,the density of RGCs declined to 71%,32% and 15% of the control group repec- tively,much higher than that of the controls on days 7,14 and 21 after optic nerve was cut off(P
