Predisposition of type 2 diabetes mellitus in elderly patients with mitochondrial DNA base variants
- VernacularTitle:线粒体基因碱基变异与老年2型糖尿病的易感性研究
- Author:
Song-Mei LIU
;
Xin ZHOU
;
Fang ZHENG
;
Xia LI
;
Han QIN
;
- Publication Type:Journal Article
- Keywords:
DNA;
mitoehondrial;
Diabetes mellitus;
type 2
- From:
Chinese Journal of Geriatrics
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the genetic predisposition to type 2 diabetes mellitus(T2 DM)and mitochondrial DNA base variants in elderly patients.Methods PCR restriction fragment length polymorphism(PCR-RFLP)analysis was used to screen base variants at position 3243 and 3426 of mitochondrial DNA in 186 elderly cases with T2 DM and 170 healthy controls,and DNA sequence was confirmed.Results No carrier of 3243 A→G variant or 3426 A→G variant was found in both groups,however there was 1 case with 3290 T→C variant in diabetic group.Conclusions No significantly association was found between mitochondrial DNA 3243 or 3426 base variants and the predisposition of type 2 diabetes mellitus in elderly patients.
