Basic fibroblast growth factor in human detrusor muscle in bladder outlet obstruction due to benign prostatic hyperplasia
- VernacularTitle:前列腺增生患者逼尿肌中碱性成纤维细胞生长因子的变化
- Author:
Zeng-Chi HAN
;
Zhong-Hua XU
;
Ben LIU
;
Lei YAN
;
Zun-Lin ZHOU
;
Hai-Nan LIU
;
Zhao-Xu LIU
;
Yi-dong FAN
;
Xiu-de CHEN
;
Bao-zhong ZHENG
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Fibroblast growth factor 2;
Bladder
- From:
Chinese Journal of Geriatrics
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of the basic fibroblast growth factor(bFGF) leve in human detrusor muscle(DM)in bladder outlet obstruction(BOO)due to benign prostatic hyperplasia(BPH)and its implication.Methods Fifty-four patients with BPH were divided into two groups:the obstructive DM stability and instability groups;and 15 men with bladder tumor who underwent operation in the same period were enrolled in the control group.The bFGF mRNA level in DM was measured by reverse transcription and polymerase chain reaction(RT-PCR)and the bFGF protein level was measured by immunohistochemical staining method.Results The bFGF-mRNA expression level of bladder smooth muscle cells was significantly lower in the control group than that in the obstructive DM stability and instability groups(all P＜0.05),but there was no significant difference between the obstructive DM stability and instability groups(P＞0.05). Conclusions The expression level of bFGF mRNA in bladder DM is elevated in BOO due to BPH,but there is little or no correlation between the increased expression of bFGF mRNA and detrusor muscle instability.
