Study on the association of serum matrix metalloproteinase-9 and white blood cell count to type 2 diabetes mellitus with macroangiopathy and the interventing treatment
- VernacularTitle:血清基质金属蛋白酶9、白细胞计数与2型糖尿病及其大血管病变的相关研究及干预治疗
- Author:
Jia LI
;
Lv-Zhi JIANG
;
Xing-Jia ZHOU
;
Xue-Ning ZHANG
;
Zheng-Fang LI
;
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase-9;
Leucocyte count;
Diabetes mellitus,type 2;
Macroangiopathy;
Atherosclerosis;
Rosiglitazone
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between serum matrix metalloproteinase-9(MMP-9), white blood cell(WBC)count and type 2 diabetes mellitus with macroangiopathy and to investigate the mechanism of the protective effects of rusiglitazone(RSG)on blood vessel.Methods Serum MMP-9 was determined by ELISA in 30 normal controls and 80 type 2 diabetic patients(including 40 cases with macroangiopathy and 40 without maeroangiopathy).WBC count and other clinical parameters were also determined.32 type 2 diabetic patients received RSG(4rag qd)for 12 weeks.All parameters were determined after 4 weeks(17 patients)and after 12 weeks(all patients)to observe the changes in MMP-9,WBC and other parameters.Results In the diabetic patients,serum MMP-9 and WBC were markedly higher as compared with normal controls;and MMP-9 and WBC in patients with macroangiopathy[579(440-949)?g/L,(7.51?1.47)?10~9/L]were higher than those [324(275-423)?g/L,(6.22?0.79)?10~9/L]in the cases without macroangiopathy(P
