Effects of extract of Gingko biloba leaves on learning,memory and hippocampus HO-1 expression In diabetic rats
- VernacularTitle:银杏叶提取物对糖尿病大鼠学习、记忆及海马血红素加氧酶1表达的影响
- Author:
Jun LIN
;
Li WEI
;
Zhi-Feng LIANG
;
Yang JIAO
;
Mei SHI
;
Zhi-Ming HUANG
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,experimental;
Learning;
Extract of Gingko Biloba;
Hippocampus;
Heme oxygenase(decyclizing)
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of extract of Gingko biloba leaves (EGb) on learning, memory and hippoeampal heine oxygenase-1 (HO-1) expression in diabetic rats.Methods The behaviors of streptozotoein-induced diabetic rats were observed by Morris water maze for learning and memory after 6 months of diabetes.The HO-1 mRNA expression and protein expression in hippocampus of diabetic rats were detected by RT- PCR and immunohistochemistry respectively.Results The escape latency time in Morris water maze of diabetic rats was prolonged markedly.HO-1 mRNA and HO-1 protein expressions in hippocampus of diabetic rats were increased (1.635?0.326 vs 0.978?0.214,7.2?1.7 vs 1.9?0.5,respectively,both P＜0.01).The escape latency times in EGb (100,50 mg/kg) treated groups were shortened.HO-1 mRNA and HO-1 protein expressions in hippocampus were decreased at the same time as compared with diabetic group (100 mg/kg:0.954?0.144,2.0?0.8;50 mg/kg:0.988?0.154,2.5?0.6,all P＜0.01).Conclusion EGb can significantly inhibit HO-1 expression in hippocampus and improve learning and memory dysfunction in diabetic rats.
