Melatonin decreases expression of transforming growth factor-?_1 in renal cortex of diabetic rats
- VernacularTitle:褪黑素降低糖尿病大鼠肾皮质转化生长因子?_1的表达
- Author:
Xiao-Wen TU
;
Ying-Jian CHEN
;
Yong-Cheng CAO
;
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Transforming growth factor-?_1;
Real-time quantitative reverse transcriptase polymerase chain reaction;
Melatonin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-?_1 (TGF-?_) mRNA or protein expression in renal cortex of diabetic rats was assessed by real-time quantitative RT-PCR with SYBR Green,immunohistochemistry or Western blot.After melatonin treatment,the expressions of TGF-?_1 mRNA and protein were decreased,suggesting that beneficial effect of melatonin may result from its antioxidative property and inhibiting TGF-?_1 expressions.
