Effects of pioglitazone and tumor necrosis factor-? on adiponectin receptor mRNA expression in 3T3-L1 adipocytes
- VernacularTitle:吡格列酮和肿瘤坏死因子?对3T3-L1脂肪细胞脂联素受体mRNA表达的影响
- Author:
Ling LIU
;
Guo-Ping HU
;
You-Min WANG
;
Ming-Gong YANG
;
- Publication Type:Journal Article
- Keywords:
Receptor,adiponectin;
3T3-L1 cells;
Cell differentiation;
Pioglitazone;
Tumor necrosis factor-?
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of pioglitazone (PIO) and tumor necrosis faetor-?(TNF-?) on two kinds of adiponectin receptor (AdipoR) mRNA expression were observed in 3T3-L1 adipocytes by RT-PCR.AdipoR mRNA expression was up-regulated during 3T3-L1 preadipocyte differentiation;PIO could increase the AdipoR mRNA level expressed in undifferentiated and differentiated 3T3-L1 adipocytes in a time-and dose-dependent manner,and TNF-?had no influence on the expression of AdipoR mRNA.
