Recombinant human interleukin-6 inhibits mRNA expressions of adiponectin,its receptor 1 and adiponectin secretion in SW872 adipocytes
- VernacularTitle:重组人白介素6抑制SW872脂肪细胞脂联素及其受体1的表达和脂联素的分泌
- Author:
Long-Jiang ZHANG
;
Han-Hua LIN
;
Hong-Wei WANG
;
Zhong-Xian BAO
;
Xiong-Hui XIAN
;
- Publication Type:Journal Article
- Keywords:
SW872 adipocytes;
Interleukin-6;
Adiponectin;
Receptor,adiponectin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
SW872 preadipocytes were cultured and induced to differentiate by oleic acid in vitro.The levels of adiponectin and its receptors (AdipoR1 and AdipoR2) mRNA were measured by semiquantitative RT- PCR.The concentration of adiponectin in the culture medium was assayed by ELISA.The results showed that rhIL- 6 could inhibit adiponectin,AdipoR1 mRNA expressions and adiponectin secretion in SW872 adipocytes in a time- and dose-dependent manner,but did not influence adipoR2 mRNA expression.
