Role of various concentrations of glucose and insulin on expression of transforming growth factor-?_1 in HK2 cells
- VernacularTitle:不同浓度葡萄糖、胰岛素对HK-2细胞转化生长因子?_1表达的影响
- Author:
Zhi-Min MIAO
;
Rui-Xia SUN
;
Zheng-Ju FU
;
Chang-Gui LI
;
- Publication Type:Journal Article
- Keywords:
Glucose;
Insulin;
Transforming growth factor-1?_1;
HK-2 cells
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
HK-2 cells were cultured with various concentrations of glucose and insulin for 12,24,48,72 h.Transforming growth factor-?_1(TGF-?_1) protein in supematant was measured by ELISA,while TGF-?_1 mRNA expression was assessed by RT-PCR.Data showed that high concentration of glucose and insulin up-regulated the expression of TGF-?_1 in HK-2 cells through different pathways.
