Successful treatment of post-transplant lymphoproliferative disorder in allogeneic hemopoietic stem cell transplant recipient for severe aplastic anemia
- VernacularTitle:造血干细胞移植后EB病毒相关性淋巴增殖性疾病一例分析
- Author:
Hui-Lan LIU
;
Zi-Min SUN
;
Liang-Quan GENG
;
- Publication Type:Journal Article
- Keywords:
Lymphoproliferative disorders;
Hematopoietic stem cell transplantation;
Herpesvirus 4,human
- From:
Chinese Journal of Organ Transplantation
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study early diagnosis and treatment of post transplant lymphoprolifer- ative disorder in allogeneic hemopoietic stem cell transplant recipients.Methods A 16 years old patient with severe aplastic anemia received HLA-mismatched sibling allogeneic hemopoietic stem cell trans- plant after conditioning with cyclophosphamide/antithymocyte globulin/methylprednisolone(CY/ ATG/MP)regimen.Results On the day 72 posttransplantation,he developed lymphoproliferative disorder.After withdrawal of CsA,he was treated with methylprednisolone,intravenous immune globulin and IFN alpha,and recovered completely from PTLD.Conclusions PTLD is a rare and fatal complication of both solid-organ and hemopoietic stem cell transplantation.Surveillance for PTLD by PCR for circulating EBV-DNA may be appropriate in high risk settings.Early diagnosis,immunosup- pression therapy reduction or even withdrawal in time is important.
