Expression changes of aldolase A and lactate dehydrogenase M following spinal cord injury in rats
- VernacularTitle:大鼠脊髓损伤后醛缩酶A和M型乳酸脱氢酶的表达变化
- Author:
Ning-Hui ZHAO
;
Yun-Xia LI
;
Xiao-Wei HUANG
;
Yi-Ping TANG
;
Lin-Feng XU
;
Deng-Li FU
;
Wei XU
;
- Publication Type:Journal Article
- Keywords:
Glycolysis;
Spinal cord injuries;
Fructose-bisphosphate aldolase;
Lactate dehydrogenase
- From:
Chinese Journal of Trauma
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the activity change pattern and corresponding significance of gly- colytic enzymes including alsolase A(ALDA)and lactate dehydrogenase M(LDH-M)regulated by hy- poxia-inducible factor 1?(HIF-1?)in spinal cord injury(SCI)of rats.Methods SD rats were ran- domly divided into control group and groups at 12 hours,1,2 and 3 days,1 and 2 weeks after compres- sive SCI,in which the activity changes of ALDA and LDH-M in the injured spinal cord were observed at different time points by means of enzyme histochemistry.Results Opitical density(A)value of AL- DA continued significant increase from two days to one week after SCI(P＜0.05)and decreased gradual- ly at 2 weeks after SCI.A value of LDH-M began significant increase at day 1 after SCI and recovered to normal level at 2 weeks after SCI(P＜0.05).Conclusion Activities of ALDA and LDH-M regulated by HIF-1?in spinal cord injury is significantly increased.
