Effect of metformin and low-fat diet on the activity of AMP-activated protein Idnase in diabetic mice
- VernacularTitle:二甲双胍和饮食因素对糖尿病小鼠骨骼肌AMPK活性的影响
- Author:
Tao YUAN
;
Jing-Hui ZHOU
;
Heng WANG
;
Qi SUN
;
Guo-Qiang ZHU
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
AMP-activated protein kinase;
Metformin;
Low-fat diet;
Mouse,KK-Ay
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
KK-Ay mice with type 2 diabetes were divided into metformin plus high-fat diet,metformin plus low-fat diet,high fat diet alone and low fat diet alone groups.AMP-activated protein kinase(AMPK)activity was measured in skeletal muscle.The results showed that metformin and low-fat diet were able to increase AMPK activity.However,no additive effect on AMPK activity by metformin and low-fat diet was found.
