Interventive effect of Angongniuhuang injection on inflammatory response after brain injury in rats
- VernacularTitle:安宫牛黄注射液对大鼠脑外伤后炎性反应的干预作用
- Author:
Chuang-Xin LIAO
;
Hai-Jun WANG
;
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Inflammation;
Interleukin-1;
Intercellular adhesion molecule-1;
Angongniuhuang injection
- From:
Chinese Journal of Trauma
1993;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Angongniuhuang injection on the level of in- terleukin-1?(IL-1?),intercellular adhesion molecule-1 (ICAM-1),serum protein S100B and neuron specific enolase (NSE) after brain injury to explore its protective effect on the injured brain tissues. Methods Brain contusion model was made in rats by Feeney's method.Then,the levels of IL-1?and ICAM-1 in the brain tissues and the levels of serum protein S100B and NSE in serum were measured by ELISA method at different time points.Results The level of IL-1?and ICAM-1 in brain tissues and that of S100B protein and NSE in serum in treatment group were lower than that in control group 6-48 hours after injury (P＜0.05).Conclusion Angongniuhuang injection can alleviate inflammatory re- sponse after brain injury and protect effectively brain tissues.
