TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor.
10.4142/jvs.2009.10.4.353
- Author:
Abel SANCHEZ-SERVIN
1
;
Simon MARTINEZ
;
Emilio CORDOVA-ALARCON
;
Raul FAJARDO
Author Information
1. Centro de Investigacion y de Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autonoma del Estado de Mexico, Carretera de cuota Toluca-Atlacomulco, Kilometro 15.5 C.P. 50200, Toluca Edo, Mexico. jsmartinezc@uaemex.mx
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
dog;
polymorphisms;
TP53;
venereal tumors
- MeSH:
Animals;
Base Sequence;
Dog Diseases/*genetics;
Dogs;
Gene Expression Regulation, Neoplastic/physiology;
Molecular Sequence Data;
Mutation;
*Polymorphism, Genetic;
Tumor Suppressor Protein p53/*genetics;
Venereal Tumors, Veterinary/*genetics
- From:Journal of Veterinary Science
2009;10(4):353-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.
