A study on the respiratory mechanics and inflammatory status in elderly patients with stable chronic obstructive pulmonary diseases.
- VernacularTitle:老年慢性阻塞性肺疾病稳定期患者呼吸力学和炎症状态的研究
- Author:
Jing FENG
;
Bao-Yuan CHEN
;
Bao-Yu ZHU
;
Jie CAO
;
Mei-Nan GUO
;
Li-Xia DONG
;
Yan WANG
;
- Publication Type:Journal Article
- Keywords:
Pulmonary diseases,chronic obstructive;
Respiratory mechanics;
Inflammation;
Cytokines
- From:
Chinese Journal of Geriatrics
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the respiratory mechanics and inflammatory status in elderly patients with stable chronic obstructive pulmonary diseases (COPD).Methods The arterial blood gases (ABGs),respiratory drive and its derivatives,mechanics of respiratory muscles,resistance and compliance of airway,interleukin-8 (IL-8)and interferon-?(IFN-?)were measured in 42 cases withstable COPD and 40 subjects of normal control.Results The elderly patients with stable COPD had great changes in the following parameters while compared with the control group:peak inspiratory pressure(PIMAX) [(4.48?2.11)vs(6.10?2.91)kPa],maximum expiratory pressure (PEMAX)[(6.30?3.20)vs(9.15?93.30)kPa],0.1s mouth occlusion pressure(P_(0.1)) with its correction index,airway resistance,compliance,ABGs,the levels of IL-8[(218.46?91.14) vs (161.84?14.40)ng/L]and IFN-?[(2435.82?639.92)vs(1652.40?95.08)ng/L],which might aggravate the progress of COPD consistently.Conclusions The elderly patiends with stable COPD has marked changes in respiratory drive,airway resistance,and airway compliance,respiratory mechanic and inflammatory status.The intervention should be performed in the elderly stable COPD patients.
