Expression of transforming growth factor-?_2 and changes of lens epithelial cells in age-related nuclear and cortex cataract
- VernacularTitle:老年核性和皮质性白内障患者转化生长因子?_2的表达及晶状体上皮细胞的变化
- Author:
Lin YE
;
Xiao-Jun CAI
;
Bai-Fang ZHANG
;
- Publication Type:Journal Article
- Keywords:
Cataract;
Transforming growth factor beta;
Lens,crystalline
- From:
Chinese Journal of Geriatrics
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogenesis of age-related cortex and nuclear cataract.Methods The levels of transforming growth factor-?_2 (TGF-?_2)mRNA,proliferating cell nuclear antigen (PCNA),ratio of Bcl-2/Bax,fibronection (FN),vimentin and the density of lens epithelial cells (LECs) were measured and compared among age-related nuclear cataract,cortex cataract and normal LECs.Results The ratio of TGF-?_2 mRNA expression/?-actin expression,the levels of PCNA protein,Bax and Bcl-2 in age-related nuclear cataract(0.16?0.02,16.01,15.97, 16.97)and in cortex cataract (0.27?0.01,1.98,16.93,1.44) were significantly different from those in normal LECs(0.15+0.02,2.43,16.84,6.12),all P
