Rosiglitazone promotes atherosclerotic plaque stability in apolipoprotein e-knockout mice
- VernacularTitle:罗格列酮增加 apoE 基因敲除小鼠主动脉粥样硬化斑块的稳定性研究
- Author:
Dong YAN
;
Quan-Ming ZHAO
;
Jin-Peng XU
;
Shu-Zheng LU
;
We WANG
;
Lu-Ya WANG
;
Dong CHEN
;
Hui-xin ZHANG
- Publication Type:Journal Article
- Keywords:
Apolipoproteins E;
Thiazolidinediones;
Chemokines
- From:
Chinese Journal of Geriatrics
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of rosiglitazone on plaque stability in ApoE-knockout mice. Methods Thirty-two 6-week-old ApoE knockout mice were used as atherosclerosis models in two groups: rosiglitazonegroup (n=18) and control group (n=14). Male and female mice were half separated into two groups. All mice were fed normal chow diet. Rosiglitazone group received rosiglitazone 17 mg/kg of body weight/day. The animals were sacrificed and aortae were prepared for analysis after fourteen weeks. Aortic root were cutted and prepared for paraffin section. The positive percentage of macrophage cells, smooth muscle cells, tumor necrosis factor-? and matrix metalloproteinase-9 in aortic lesions were measured by immunohistochemistry. The changes of grey gradient of collagen in lesion of both groups were measured by Masson stain. Results The positive percentage of smooth muscle cells [(38.5?7.2)%vs(18.6?6.7)%,P
