Association of highly sensitive C-reactive protein with insulin sensitivity index and adiponectin in patients with newly diagnosed type 2 diabetes and impaired glucose tolerance
- VernacularTitle:糖耐量受损和2型糖尿病患者血清C反应蛋白与胰岛素敏感指数、脂联素的关系
- Author:
Guoyue YUAN
;
Libin ZHOU
;
Jinfeng TANG
;
Ying YANG
;
Weiqiong GU
;
Fengying LI
;
Jie HONG
;
Yanyun GU
;
Min XU
;
Pengfei DU
;
Xiaoying LI
;
Guang NING
;
Mingdong CHEN
- Publication Type:Journal Article
- Keywords:
Impaired glucose tolerance;
Diabetes mellitus, type 2;
C-reactive protein;
Adiponectin;
Insulin sensitive index
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible correlation between serum highly sensitive C reactive protein (hs CRP) and blood glucose, insulin, lipids ,insulin sensitivity index (SI),acute insulin response(AIR), and adiponectin in subjects with impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes mellitus(DM). Methods SI and AIR were assessed by the reduced sample number of Bergman′s minimal model method by intravenous glucose tolerance test in subjects. Meanwhile body mass index (BMI), waist hip ratio (WHR), the serum lipid profile, hs CRP, adiponectin levels were measured. Results Compared with normal control (NC) group[SI(6.6?2.4) 10 -4 (min?mU/L) -1 ,adiponectin7.77(6.35 10.70 mg/L),hs CRP0.40(0.21 1.67mg/L)], the SI and serum adiponectin in IGT group [(1.5?1.1) 10 -4 (min?mU/L) -1 , 4.29(3.59 6.22 mg/L) respectively] and type 2 DM group [(1.5?1.0)?10 -4 (min?mU/L) -1 , 3.46(2.37 4.72 mg/L) respectively] were significantly decreased (all P
