Association of single nucleotide polymorphism in glucagon-like peptide-1 receptor gene with type 2 diabetes in Shanghai
- VernacularTitle:上海地区胰升糖素样肽1受体基因多态性与2型糖尿病相关
- Author:
Shen ZHENG
;
Tianhong LUO
;
Yu ZHAO
;
Guo LI
;
Min LIU
;
Yanyun GU
;
Hongli ZHANG
;
Youping LIU
;
Min LUO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Insulin secretion;
Polymorphism, single nucleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of glucagon like peptide 1 receptor (GLP1R) gene polymorphism with type 2 diabetes in Han population in Shanghai. Methods In the study, 360 type 2 diabetic patients and 313 normal control subjects were enrolled. Diabetic patients were further subdivided into insulin treated non obese patients (BMI28, 192 subjects). A single nucleotide polymorphism (SNP) rs 2268657 was genotyped in all the subjects enrolled in the study using allele specific real time PCR and its association with type 2 diabetes was examined. Results The frequencies of AA,AG, GG genotype incontrol group were0.086,0.447, 0.466 respectively, 0.155, 0.375, 0.470 in non obese diabetic patient group respectively, and 0.109, 0.500, 0.391 in obese diabetic patient group respectively. There was significant difference of the frequency of genotype AA between control group and non obese diabetic patient group (OR=1.939, P
