Effects of alcohol intake on the expressions and phosphorylations of insulin receptor and insulin receptor substrates in rat skeletal muscle
- VernacularTitle:饮酒对大鼠骨骼肌胰岛素受体及其底物表达和磷酸化的影响
- Author:
Qiang WAN
;
Ling GAO
;
Yi LIU
;
Jiajun ZHAO
;
- Publication Type:Journal Article
- Keywords:
Ethanol;
Insulin sensitivity;
Muscle, skeletal;
Rats, Wistar
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of alcohol intake for 5 months on insulin stimulated glucose uptake,expression levels and tyrosine phosphorylations of insulin receptor (IR), IR substrate (IRS) 1 and IRS 2 in rat skeletal muscle were observed. Results showed that alcohol consumption could impair insulin stimulated glucose uptake in rat skeletal muscle, accompanied by the up regulated expression and tyrosine phosphorylations of IR, IRS 1 and IRS 2.
