Study of a 27-bp variable number of tandem repeat polymorphism of the endothelial nitric oxide synthase gene in patients with transient ischemic attack of brain
- VernacularTitle:短暂性脑缺血发作患者一氧化氮合酶基因碱基重复序列多态性研究
- Author:
Yu-Qiang SONG
;
Chen ZHANG
;
Hongli ZOU
;
- Publication Type:Journal Article
- Keywords:
Nitric-oxide synthase;
Polymorphism,single nucleoticle;
Base sequence;
Ischemic attack,transient
- From:
Chinese Journal of Geriatrics
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between a 27-bp variable number of tandem repeat(VNTR) polymorphism of the endothetial nitric-oxide synthase(eNOS)gene and transient ischemic attack(TIA) of brain.Methods Polymerase chain reaction was performed for the genotypes of all patients and control subjects.Data were compared between patients and control subjects using ?~(2)test. Results The genotype ab distribution and allele a frequencies of eNOS gene were significantly higher in TIA group(25.0%,14.3%) than in control group(16.3%,9.2%)(P
