Effect of inosine on the discharge of isolated toad muscle spindle

VernacularTitle:肌苷增强蟾蜍离体单一肌梭传入放电频率
Author: Lei SHI ; Xiaoli FAN ; Sudi WU ; Xin'Ai SONG ;
Publication Type:Journal Article
Keywords: afferent discharge; isolated muscle spindle; inosine
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2004;0(05):-
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of inosine on afferent discharge of muscle spindle.Methods The afferent discharge of isolated toad muscle spindle was recorded using air-gap technique.The effects of inosine on the discharge rate of muscle spindle was observed.Results After administration of 0.2mmol/L,0.4mmol/L and 0.8mmol/L inosine,the spontaneous discharge of muscle spindle increased from(0.86?(0.12))Hz,(0.88?(0.12))Hz and(0.85?0.10)Hz to(11.42?2.48)Hz,(21.75?3.03)Hz and(32.25?4.08)Hz,respectively.Conclusion Inosine can increase the afferent discharge rate of muscle spindle,and this effect is dose-dependent.