Expression and clinical significance of urokinase type plasminogen activator in giant cell tumor of bone
- VernacularTitle:尿激酶型纤溶酶原激活物系统在骨巨细胞瘤中的表达及临床意义
- Author:
Jian QIN
;
Wanchun WANG
;
Zhonghe XU
;
- Publication Type:Journal Article
- Keywords:
Giant cell tumor of bone;
Urokinase type plasminogen activator;
Immunohistochemistry;
Tumor relapse
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of uPA and uPA R protein expression in bone giant cell tumors(GCT)with their pathological grades and relapse. Methods By using Avidin biotin complex(ABC) immunohistochemistry method, monoclonal antibodies against uPA and uPA R proteins were used to measure their expression in 23 cases of GCT (including 8 cases of pathological grade Ⅰ, 10 cases of pathological grade Ⅱ and 5 cases of pathological grade Ⅲ accord to Jaffe classification). Results According to the level of these immunoreaction, over expression of uPA and uPA R were detected in 10 and 8 patients (positive rate 43.5 % and 34.8 %). In cases with relapse or not, the positive expression rate of uPA and uPA R was 66.7 %, 28.6 %, 66.7 %, 14.3 % respectively, abnormally high expression of both uPA and uPA R proteins was found in 6 cases(66.7 %). A significant correlation existed between the uPA R expression or co over expression of uPA and uPA R proteins in GCT and its relapse (P
