Effect of telmisartan on the levels of serum adiponectin and C-reactive protein in elderly hypertensive patients with unstable angina pectoris
- VernacularTitle:替米沙坦对老年高血压不稳定性心绞痛患者脂联素及C反应蛋白的影响
- Author:
Ze-Peng LIN
;
Guang-Lin JIN
;
Zhi-Wei ZHANG
;
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Receptors, angiotensin AI;
Peroxisome proliferator-activated receptors;
C-reactive protein
- From:
Chinese Journal of Geriatrics
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the effect of telmisartan on the levels of serum adiponectin and C-reactive protein(hs-CRP)in elderly hypertensive patients with unstable angina pectoris. MethodsOne hundred and twenty elderly hypertensive patients with unstable angina pectoris were randomized into two groups, telmisartan(n=60) and perindopril(n=60) groups.The levels of hs-CRP,adiponectin, lipid factors, fasting plasma glucose (FPG), insulin and insulin sensitivity index (ISI) were measured before and 6 months after telmisartan and perindopril treatments.ResultsAt the end of 6 months, the telmisartan group showed more reduction in plasma levels of hs-CRP and more increment in serum adiponectin concentrations and ISI significantly. The frequency of cardiovascular events was significantly lower in the patients of the telmisartan group than that of the perindopril group.ConclusionsCompared with perindopril, telmisartan significantly decreases plasma levels of hs-CRP and increases serum adiponectin concentrations in elderly hypertensive patients with unstable angina pectoris. It also significantly decreases the frequency of cardiovascular events in these patients.
