Mutagenicity of Organic Extract From Drinking Water in a Certain City
- VernacularTitle:某市生活饮用水有机浓集物的致突变性
- Author:
Qing-Bi ZHANG
;
Zhi-Qun CHEN
;
Zhong-Lin GAN
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Water contamination Mutagenicity test Ames test Primary hepatocytes Single cell gel-electrophoresis
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To have a knowledge of the mutagenicity of contaminates in drinking water in a certain city. Methods Mutagenic activity of organic extracts of source water chloridized water in water plant and tap water from the city were detected with single cell gel-electrophoresis mouse primary hepatocytes in culture were used and Ames test. Results For Ames test the organic extract in 3 liters chloridized water in water plant and tap water samples produced positive result and that in 6 liters source water sample still gave a negative result. For single cell gel-electrophoresis test the organic extract in 0.1 liter chloridized water in water plant tap water and 0.5 liter source water produced positive result. Conclusion The sensitivity of single cell gel-electrophoresis with primary hepatocytes in detection of genotoxicity of cloridized water and source water is much higher than Ames test.
