Effects of saturation of free fatty acids on nitric oxide and endothelin production in cultured human vascular endothelial cells
- VernacularTitle:游离脂肪酸饱和度对内皮细胞一氧化氮及内皮素合成的影响
- Author:
Yuwei DI
;
Guangyao SONG
;
Zhihua WANG
;
Ying QIN
;
Yongmei ZHANG
;
- Publication Type:Journal Article
- Keywords:
Endothelial cells;
Fatty acids, nonesterified;
Fats, unsaturated;
Nitric oxide;
Endothelins
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Corresponding author: SONG Guang yao Human umbilical venous endothelial cells (HUVEC) were incubated with free fatty acids (FFAs) of various degrees of saturation. C18:1 and C18:2 inhibited the synthesis of nitric oxide (NO) and endothelin (ET) in HUVEC, and ET synthesis was inhibited much more than NO synthesis, and C18:0 increased ET synthesis in HUVEC, suggesting that the effects of FFAs on HUVEC were related to their degree of saturation.
