Association between the G1181C polymorphism of osteoprotegerin gene and bone mineral density in postmenopausal women
- VernacularTitle:绝经后妇女护骨素基因G1181C多态性与骨密度变化相关
- Author:
Hongyan ZHAO
;
Jianmin LIU
;
Guang NING
;
Huaidong SONG
;
Ying CHEN
;
Lianzhen ZHANG
;
Lihao SUN
;
Yongju ZHAO
;
Manyin XU
;
Jialun CHEN
;
- Publication Type:Journal Article
- Keywords:
Gene, osteoprotegerin;
Polymorphism, single nucleotide;
Bone density;
Postmenopause
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To search the single nucleotide polymorphism (SNP) in exons of osteoprotegerin gene, and to analyse the relationship between SNP and bone mineral densities (BMD) in postmenopausal women. Methods Using PCR and direct sequencing to identify SNP and genotypes in 205 postmenopausal women. BMD at lumbar spine (L 2 4 ) and femoral neck (FN) were measured by dual energy X ray absorptiometry. Serum osteocalcin (BGP), osteoprotegerin (OPG), osteoprotegerin ligand (RANKL) and urinary N telopeptides of type Ⅰ collagen (NTx) were also measured. Results One SNP, G1181C, was found in exon 1 of OPG gene. The frequencies of G1181C genotypes in 205 postmenopausal women were 0.566, 0.346, and 0.088 for the genotypes GG, GC and CC respectively. BMD at lumbar spine (L 2 4 ) of CC genotype was significantly higher than GC and GG genotypes (P
