Improvement of high glucose toxicity-induced insulin desensitivity by nitric oxide in diabetic rats
- VernacularTitle:一氧化氮改善糖尿病大鼠高糖毒性导致的胰岛素敏感性下降
- Author:
Ling LI
;
Yanqing HAN
;
OSHIDA YOSHIHARU
;
Yuzo SATO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, experimental;
Glucose toxicity;
Insulin resistance;
Nitric oxide;
Euglycemic hyperinsulinemia clamp technique
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe whether nitric oxide (NO) improves high glucose toxicity induced insulin resistance in streptozotocin (STZ) induced diabetic rats. Methods The changes of metabolic clearance rate for glucose (MCR), as the index of insulin effect, were observed in 24 STZ induced diabetic rats and 24 normal rats in awake condition treated by sodium nitroprusside (SNP), N G monomethyl L arginine (LNMMA), adenosine or saline duringeuglycemichyperinsulinemiaclampprocedure.Results MCR in saline treated diabetic rats 〔(7.2?0.8)ml?kg -1 ?min -1 〕 wassignificantlylowerthanthat in normol control rats 〔(18.0?1.8)ml?kg -1 ?min -1 , P
