The inhibitory effects of a novel HLA-derived peptide on the immune function of rat splenocytes
- VernacularTitle:新型HLA衍生肽对大鼠脾细胞免疫功能的抑制作用
- Author:
Shanhong YI
;
Bo SONG
;
Zehou WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Histocompatibility antigens;
Heme oxygenase
- From:
Chinese Journal of Organ Transplantation
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the immunosuppression function of a novel HLA derived peptide, RDP1258, and to investigate the mechanisms. Methods The peptides derived from HLA, RDP1258, and HLA 2702.75 84 was synthesized chemically. The effects of the peptides on alloreactive cytotoxic activities of rat spleen cells were observed using 3H TdR incorporation method. The heme oxygenase 1 activity was detected by the enzyme chemistry method. Result The synthetic HLA derived peptides could obviously inhibit the proliferation of rat spleen cells and HO 1 activity in a dose dependent manner in vitro. Conclusion HO 1 may participate in the process of inhibitory effect of RDP1258 on the proliferation of rat spleen cells induced by mitogen or isoantigen.
