Study of ~1H-and ~(31)P-MRS in rat brain under chronic cerebral ischemia
- VernacularTitle:慢性脑缺血大鼠~1H和~(31)P活体核磁共振波谱分析
- Author:
Junjian ZHANG
;
Yan ZHOU
;
Yue FENG
;
Maili LIU
;
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Geriatrics
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the biochemical alterations in rat brain under chronic cerebral ischemia by means of 1H and 31 P magnetic resonance spectroscopy (MRS) Methods Chronic cerebral ischemia was induced by permanent bilateral commom carotid artery occlusion (2 VO)in the regions of the hippocampal CA1 area and the whole brain. Results In vivo 1H MRS did not reveal any significant change in the concentrations of N acetyl aspartate (NAA) and Lactate (Lac) in the hippocampal CA1 region 31 P MRS in the whole brain showed an elevation of phosphomonoesters (PME). The ratio of PME/(PME+PDE) was 0 54?0 03 in sham group and 0 69?0 02 in 2 VO group ( P
