Detection of Spreading Scope of Rectal Cancer to Mesorectum with RT-PCR and Its Clinical Significance
- VernacularTitle:RT-PCR检测直肠癌在直肠系膜的播散范围及临床意义
- Author:
Xiaolin WANG
;
Sanhua QING
;
Xiangcheng HUANG
;
Jingxiang SONG
;
Chengtang WU
;
- Publication Type:Journal Article
- Keywords:
RT-PCR Carcinoembryonic antigen Rectal cancer Mesorectum
- From:
Chinese Journal of Bases and Clinics in General Surgery
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the spreading scope of rectal cancer to mesorectum by RT PCR using carcinoembryonic antigen (CEA) mRNA as a marker and to investigate the excision scope of mesorectum in resection of rectal cancer. Methods Forty specimens from 40 rectal cancer patients who underwent curative operation was employed to detect the metastatic deposits scattered in the mesorectum by RT PCR using CEA as a marker. Results Nine of 40 (22.5%) specimens contained metastatic deposits scattered in the mesorectum. The metastasis was just within the range of 4cm mesorectum under the verge of tumor. The tumor spreading to mesorectum is correlated with Dukes stages,the infiltrated depth of bowel wall, tumor differentiation and tumor type( P 0.05). Conclusion The excision of mesorectum should be within the range of 5cm under the verge of tumor in surgical management of rectal cancer.
