The study of relationship between the mutation of 5′noncoding region of BCL-6 gene and extranodal diffuse large B cell lymphoma
- VernacularTitle:BCL-6基因5′非编码区点突变与结外弥漫大B细胞淋巴瘤的相关性研究
- Author:
Zhenxia LU
;
Xiaoxia CHEN
;
Yanxia SUN
;
Butong SUN
;
Hua YANG
;
- Publication Type:Journal Article
- Keywords:
B cell lymphoma;
Big cell lymphoma;
Diffuse;
Mutation
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the mutation of 5′ noncoding region of BCL 6 gene in extranodal diffuse large B cell lymphoma (DLBCL) and the relationship between mutation and clinical characteristics.Methods:Extract DNA from paraffin bedded extranodal DLBCL cases,then PCR and sequenced.Meanwhile retrospective analysis was done.Results:The mutation rate was 13 64%(6/44).The clinical characteristics,such as age、sex、B symptom、bulky tumor mass、stage、the level of LDH、BM involvement and CR,had no significant influence on BCL 6 mutation;the survive time of DLBCL with/without BCL 6 mutation had no obvious difference,but there was a tendency the survival time of mutated patients was longer than that of non mutated (the mean survival time was 74 and 65 02 months,respectively);mutation wasn't an independent prognostic factor.Conclusion:The mutation of 5′ noncoding region of BCL 6 gene maybe partly involves in the mechanism of extranodal DLBCL. [
