Study of immunoregulatory activity of rhizoma menipermi extracts on mouse and human lymphocytes and macrophages in vitro
- VernacularTitle:北豆根提取物对小鼠和人淋巴细胞及巨噬细胞作用的体外实验研究
- Author:
Wenjie LIANG
;
Dongqing LIU
;
Baoen SHAN
;
Jing ZHANG
;
Qiaoxia LI
;
- Publication Type:Journal Article
- Keywords:
Rhizoma menipermi active component;
Immunoregulatory activity;
Macrophages;
Lymphocytes
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the immunoregulatory activity and mechanisms of Chinese medicinal herb Rhizoma Menipermi extracts.Compare the biological activity of Rhizoma Mednispermi extract with water (RMW),ethanol (RME) and Rhizoma Menispermi Polysaccharide (RMP).Methods:The chemical composition of Rhizoma Menipermi extract was separated with water,ethanol extraction and distillation methods.The effect of Rhizoma Menipermi extracts on lymphocytes and the effect on the metabolism and phagocytosis of mouse macrophages were studied by MTT colorimetric method and neutrol red method.Results:RMP can stimulate the proliferation of mouse spleen cells and human lymphocytes and enhance the metabolism and phagocytosis of mouse macrophages.RMW and RME have inhibitory effect on mouse spleen cells and human lymphocytes and mouse in vitro,and inhibited the metabolism and phagocytosis of mouse macrophages.Conclusion:Diffrent Rhizoma Menipermi composition showed diffrent effects on lymphocytes,RMW and RMP can be used for the supplementary treatment of cancer. [
