1H MR Spectroscopy in Parkinson's Disease and Progressive Supranuclear Palsy: Preliminary Study.
10.3348/jkrs.1996.34.6.711
- Author:
Kee Hyun CHANG
1
;
Beom Seok JEON
;
In Chan SONG
;
Dong Sung KIM
;
Kwan Hong MIN
;
Moon Hee HAN
;
Sa Ouk KANG
;
Byoung Goo MIN
;
Man Chung HAN
Author Information
1. Department of Diagnostic Radiology, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Magnetic resonance(MR), spectroscopy;
Brain, atrophy;
Brain, diseases
- MeSH:
Corpus Striatum;
Humans;
Lactic Acid;
Magnetic Resonance Spectroscopy*;
Neurons;
Parkinson Disease*;
Putamen;
Steam;
Supranuclear Palsy, Progressive*
- From:Journal of the Korean Radiological Society
1996;34(6):711-716
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiating idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios. MATERIALS AND METHODS: Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of 135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions of interest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. ESULTS: NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 +/-0.26 versus 1.45 +/-0.20, and 1.26 +/-.23 versus 1.38 +/-0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 +/-0.21 versus 1.76 +/-0.15, and 1.36 +/-0.13 versus1.79 +/-0.17, respectively : p<0.05). However, NAA/Cho and NAA/Cr ratios between age-matched controls and IPD werenot significantly different (p>0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. CONCLUSION: NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSP group than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differential diagnosis of IPD and PSP.
