The changes of functions of chemokine receptor 9 on T cell lymphocytic leukemia patients
- VernacularTitle:T淋巴细胞性白血病病人CCR9的功能改变
- Author:
Zhifang HU
;
Qiuping ZHANG
;
Huimin CHEN
;
Xinggao DONG
;
Luokun XIE
;
Yuling HE
- Publication Type:Journal Article
- Keywords:
CCR9;
TECK;
T ALL;
T CLL
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the influences of functions of chemokine receptor 9(CCR9) on leukemia patients,we analyzed 38 typical T cell lymphocytic leukemia cases.Methods:The functions of T ALL and T CLL CD4+T cells towards TECK/CCL25 were determined by chemotaxis assay and adhesion assay.Results:Almost in all of the T ALL patients,TECK/CCL25(a ligand for CCR9)could induce a high chemotactic migration of T ALL CD4+ cells as well as a high adhesion.Conclusion:It indicates that CCR9 and its ligands may promote survival or proliferation of T ALL cells. [
