Effects of fluvastatin on the tubulointerstitium in progressive diabetic kidney disease
- VernacularTitle:氟伐他汀对糖尿病大鼠肾小管间质病变的保护作用及其机制
- Author:
Ping GAO
;
Ruhan JIA
;
Guili CHU
;
Enfeng SONG
;
Guohua DING
;
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Antilipemic agents;
Transforming growth factor beta
- From:
Chinese Journal of Geriatrics
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of fluvastatin on the tubulointerstitium damage in progressive diabetic kidney disease. Methods A rat model of type 2 diabetic nephropathy (DN) was developed successfully by combination of dietary induced insulin resistance and low dose STZ induced hyperglycemia after unilateral nephrectomy. Female SD rats were randomly divided into three groups: control rats, type 2 diabetic rats and type 2 diabetic rats treated with fluvastatin (2mg/kg/d). After 6 weeks, blood glucose, serum insulin, serum triglyceride and cholesterol, serum creatinine, and urinary protein were measured respectively. The protein expressions of c Jun and tansforming growth factor (TGF) ? 1 were studied by immunohistochemistry. TGF ? 1 gene expression was studied with a RT PCR technique. Results Fluvastatin at lower doses, which did not influence blood glucose and blood lipid level, significantly inhibited expression of c Jun protein(0 2536?0 0180 vs 0 5855?0 0314, P
