Effects of methylprednisolone on serum S-100B protein and neuron specific enolase in rats with brain injuries
- VernacularTitle:甲基强的松龙对脑损伤大鼠血清神经组织蛋白S100和神经元特异性烯醇化酶的影响
- Author:
Chuangxin LIAO
;
Haijun WANG
;
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Phosphopyruvate hydratase;
Nerve tissue protein S100;
Methylprednisolone
- From:
Chinese Journal of Trauma
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the role of methylprednisolone in treatment of brain injuries through comparing the changes of serum S 100B protein and neuron specific enolase (NSE) levels. Methods Seventy two rats with brain contusion made by frontoparietal bone windows plasty with extradural hitting were divided into three groups: control group ( n =32), normal group ( n =8) and treatment group ( n =32) that were subdivided into groups 1, 6, 12 and 24 hours after injury. The levels of S 100B protein and NSE were measured at different time points after hitting by ELISA. Results ①The levels of serum S 100B protein and NSE was (0.35?0.03) ?g/L and (8.35?1.01) ?g/L, respectively in normal group. The levels of serum S 100 B protein and NSE in control group and treatment group (6 24 hours post injury) were higher than those in normal group ( P
