Relationship between microchimerism and immunologic tolerance after kidney transplantation
- VernacularTitle:嵌合体与同种异体肾移植免疫耐受相关性的研究
- Author:
Yaowen FU
;
Wenlan ZHANG
;
Weigang WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Chimra;
Immune tolerance
- From:
Chinese Journal of Urology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between microchimerism and immunologic tolerance in kidney transplantation recipients. Methods In samples of peripheral blood and urinary sediment from 176 females who received male donor's kidney,DNA and mRNA expression of specific fragment in Y chromosome were determined by PCR and RT PCR. Results The test results were positive for chimerism in 137 out of 176 recipients(77.84%),and negative in 39 cases (22.16%).The mean survival period in chimerism positive group was 8.9?3.7 years,and 5.2?3.9 years in chimerism negative group.The difference was statistically significant between the 2 groups ( P
