Protective Effects of VE on Renal Proximal Tubular Cells of Mice With Chronical Cadmium Poisoning
- VernacularTitle:维生素E对慢性镉染毒小鼠肾近端小管细胞损伤的保护作用
- Author:
Min SU
;
Yue HUANG
;
Fengrong JIANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Vitamin E;
Cadmium;
Renal proximal tubular;
Apoptosis;
Stereological analysis
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study protective effects of vitamin E(VE) on renal proximal tubular cells of mice treated with cadmium chronically. Methods 75 Kunming mice were divided into 3 groups randomly, cadmium group, VE group, control group. The mice in cadmium group were treated with cadmium in 2 mg/kg by subcutaneously injected, twice per week, in VE group they were treated with VE in 10 mg/(kg?d) additionally, in control group the animals were treated with saline only. 3 months later the finestuctural changes of the renal proximal tubule cells were observed by electron microscopy and immunohistochemistry(Tunel method). The ultrastuctures of nuclei were revealed with stereological analysis. The apoptotic cells were counted with image analysis. Results The structure of the renal proximal tubule cells of mice in the VE group was similar to those in the control group, but it had significant changed compared with those of the cadmium group. Compared with the control group, the nuclear important morphological parameters of VE group increased significantly (P
