Effect of apolipoprotein E gene polymorphism on serum lipid level before and after renal transplantation
- VernacularTitle:载脂蛋白E基因多态性对肾移植前后血脂水平的影响
- Author:
Yuxin WANG
;
Huaifu LI
;
Yuanshan LU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Lipids;
Apolipoproteins E;
Gene expression
- From:
Chinese Journal of Organ Transplantation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of apolipoprotein E (ApoE) gene polymorphism on lipid metabolism of renal transplant recipients before and after transplantation. Methods ApoE gene polymorphism was detected by Polymerase chain reaction restriction fragment length polymorphism and serum lipid levels were measured by biochemical method. Results Serum lipid levels in the recipients were increased significantly at 3rd month after renal transplantation, and were ulteriorly elevated at 6 th month and the first year. The patients with higher total serum cholesterol (TC) and triglyceride (TG) levels were only accounted for 2.9 % and 7.6 % respectively before renal transplantation, but for 28.6 % and 46.7 % respectively at 3rd month after renal transplantation ( P
