Association between the polymorphism of CYP17 gene and risk of prostate cancer in Chinese men
- VernacularTitle:中国汉族男性CYP17基因多态性与前列腺癌发生危险性的关系
- Author:
Junqi WANG
;
Mire GULI
;
Hongwei LI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Genes;
Polymorphism
- From:
Chinese Journal of Urology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the polymorphism of CYP17 gene and the risk of prostate cancer. Methods A case control study including 125 prostate cancer patients and 158 age matched controls was conducted.The polymorphism was investigated by PCR using DNA from peripheral blood lymphocytes. The transition (T→C) in the risk allele (A2) produced a new recognition site for the restriction enzyme MspA1.Three genotypes of CYP17 gene (A1/A1,A1/A2,A2/A2) were determined and confirmed by sequencing. Results The frequency of the A2 allele was similar in the cases and controls.Compared with men with A1/A1 genotype, the odds ratios were 1.19 and 1.28 for the A1/A2 and A2/A2 genotypes,respectively.However,stratification by age of prostate cancer cases revealed that among prostate cancer cases older than 69 years,the odds ratio was 3.97 and 3.21 for the A1/A2 and A2/A2 genotypes ( P =0.007,0.023,respectively).Meanwhile,comparison among 3 subgroups (division by genotypes) of controls,the fPSA and tPSA levels were not significantly different. Conclusions These results indicate that A2 allele does not increase the risk of prostate cancer in Chinese. But in men older than 69 years,A1/A2 and A2/A2 genotypes predict susceptibility to prostate cancer. It is suggested that CYP17 gene may be associated with the morbidity of prostate cancer in elderly male population.
