Immune response in mice innoculated by NDA vaccine expressing chimeric gene gag-gp120 of HIV-1
- VernacularTitle:表达HIV-1 gag-gp120嵌合基因的DNA疫苗在小鼠体内的免疫应答
- Author:
Wenzheng JIANG
;
Ningyi JIN
;
Zijian LI
;
Lishu ZHANG
- Publication Type:Journal Article
- Keywords:
HIV-1;
gag-gp120;
DNA vaccine;
Immune response
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the immune response in mice inoculated by DNA vaccine expressing chimeric gene gag gp120 of HIV 1.Methods:After BALB/C mice were immunized by the eukaryotic expression plasmid pVAXGE,the numbers of T lymphocyte subgroups of spleen,the killing rate of specific CTL from the immunized mice and the titers of serum antibodies during the different time were observed.Results:The lymphocytes of the immunized group by recombinant plasmid pVAXGE proliferated,the specific CTL killing rate of spleen was higher significantly than those of the control group( P
