mRNA expression of CD28/B7 molecules in the peripheral blood mononuclear cells of the patients with systemic lupus erythematosus and their significance
- VernacularTitle:系统性红斑狼疮外周血单个核细胞CD28/B7分子mRNA的表达
- Author:
Juanqin GONG
;
Zhiqiang CHEN
;
Zijia HU
;
Wenzhong LI
- Publication Type:Journal Article
- Keywords:
Systemic Lupus Erythematosus;
Costimulatory molecule;
CD28;
B7
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the roles of CD28/B7 molecules expression in the pathogensis of systemic lupus erythematosus and their significance.Methods:Applying reverse transcription polymerase reactin(RT PCR)technique to semiquantitatively analyze CD28?B7 1 and B7 2 mRNA expression in the Peripheral Blood Mononuclear Cells(PBMC)from 35 active SLE patients and 30 cases of healthy subjects.Results:Compared with normal controls,the positive rate of CD28 expression in active SLE patients accounted for 22 86%,which was markedly lower than the normal controls(70 00%),the difference was statistically significant( P
