Biphenotypic Acute Leukemia with BCR-ABL mRNA Transcript b3a2 Type: A Case Report with Review of the Literature.
10.3343/kjlm.2006.26.4.249
- Author:
Hyun Woo CHOI
1
;
Myung Geun SHIN
;
Hyeoung Joon KIM
;
Il Kwon LEE
;
Ju Hyun YUN
;
Hye Ran KIM
;
Yeo Kyeoung KIM
;
Hyeong Kee YUN
;
Duck CHO
;
Seung Jung KEE
;
Jong Hee SHIN
;
Soon Pal SUH
;
Dong Wook RYANG
Author Information
1. Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea. mgshin@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Biphenotypic acute leukemia (BAL);
Ph chromosome;
BCR-ABL mRNA transcript
- MeSH:
Adult;
Child;
Classification;
Humans;
Karyotype;
Leukemia;
Leukemia, Biphenotypic, Acute*;
Philadelphia Chromosome;
Prognosis;
RNA, Messenger*;
World Health Organization
- From:The Korean Journal of Laboratory Medicine
2006;26(4):249-254
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Biphenotypic acute leukemia (BAL) is a subtype of leukemia of ambiguous lineage in the World Health Organization classification system. About one third of the cases have the Philadelphia chromosome, and some cases are associated with other structural abnormalities involving 11q23. BAL is known to have a poor prognosis in both children and adults. According to the previously reported BAL cases with positive BCR-ABL fusion gene, most of the BCR-ABL mRNA transcript type was e1a2. So, we describe here a 30-year-old adult BAL case with the karyotype 46,XY,t(9;22)(q34;q11.2) resulting in a very rare b3a2 type of BCR-ABL mRNA transcript.
