Detection of Ryanodine receptor antibody in sera of myasthenia gravis patients and its clinical significance
- VernacularTitle:重症肌无力患者血清中Ryanodine受体抗体检测及其临床意义
- Author:
Xiang ZHANG
;
Jian QIAO
;
Chuan-Zhen LV
;
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Thymoma;
Ryanodine receptor calcium release channel;
Antibodies
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance to detect the Ryanodine receptor (RyR) antibody in the sera of myasthenia gravis (MG) patients.Methods Sarcoplasmic reticulum abound with RyR was extracted by centrifugation,and levels of antibodies in 66 MG patients with thymoma (MGT),98 non-thymoma MG (NTMG) patients,50 non-myasthenia gravis (NMG) patients and 123 normal persons were examined by ELISA-RyR method.Results RyR antibody positive rate of MGT was the highest among MGT,NTMG and NMG groups ( P 0.05).Ages,clinical scores and levels of acetycholine receptor antibodies of patients with RyR antibody positive sera were higher than those with RyR antibody negative sera ( P
