Experimental study of neurotrophic activity of Schwann cells-derived neurotrophic factor on developing motoneurons
- VernacularTitle:许旺细胞源神经营养因子对发育期运动神经元效应的实验研究
- Author:
Yangbin XU
;
Ping LI
;
Jiakai ZHU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Schwann cells;
Neurotrophic factors;
Motoneurons;
Facial nerve nucleus
- From:
Chinese Journal of Microsurgery
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the neurotrophic activity of Schwann cells derived neurotrophic factor (SDNF) on developing motoneurons Methods The right facial nerve of 14 neonatal SD rats was transected neonatal SD rats was transected. The rats were randomly divided into two groups. SDNF (10?g/d) was applied for 7 days in experimental group and PBS(loul) was received in contral group. The mounts and morphology of motoneurons were studied. Results The number and morphometry of experimental group was better than that of controlled group significantly. Conclusion SDNF could save facial motoneurons fron axotomy induced cell death in neonatal rats.
