Effect on radiosensitivity of human lung adenocarcinoma cells transfected with wild-type p16 gene
- VernacularTitle:转染p16基因对人肺腺癌细胞放射效应的影响
- Author:
Xiumei MA
;
Qingshan YOU
;
Songbin FU
;
Al ET
- Publication Type:Journal Article
- Keywords:
p16 gene;
transfection;
tumor cell;
radiation effect
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05); The result of FCM indicates that the cells transfected with p16 changed in cell cycle distribution ; proportion of G 2 M phase was increased, while that of S phase was decreased.Conclusions:Introduction of p16 gene into low expression human lung adenocarcinoma cell line Anip973 alters the radiation effect in a way which perhaps was correlated with the inhibition of sublethal damage repair and the cell cycle distribution change, but not in the high expression cell line AGZY83a.
